En-Chih developed an effective synthesis of F2-TCNQ, which is a molecule to be used by the Massari lab! I hope their experements work as well as this synthesis. Congrats En-Chih.
Congratulations to Ryan Daley on his 3rd pub from the lab and the labs 19th independent publication. This mini review covers recent progress in the area of Pd catalyzed decarboxylative cross-coupling. The good news is that pubs 20-22 are not too far off so stay tuned for more to come.
We were recognized with the JST Safest Lab Award for Fall 2019! Congrats Topczewski lab! Please maintain the vigilant and conscientious safety minded approach to research. Thank you all for the dedication in maintaining excellence in safety!
Prof. Topczewski was quoted in a Popular Science article discussing a recent fatal accident at a Buffalo Wild Wings - https://www.popsci.com/story/science/safe-cleaning-agents-use/ It is a tragic retelling of a classic story – read the label and don’t mix bleach with other cleaners. Hopefully, the discussion was refocused a bit.
Congrats to Angela for her outstanding work on developing bromodomain inhibitors. Her latest paper (https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00227) was highlighted as an in this issue "https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00389". Keep up the great work!
Congrats to Ryan and En-Chih! Our recent paper on decarboxylative cross-coupling (https://pubs.acs.org/doi/10.1021/acs.orglett.9b01620) is highlighted in OPR&D (https://pubs.acs.org/doi/10.1021/acs.oprd.9b00327).
Congratulations to Tim for being awarded an Undergraduate Research Opertunity for the Fall of 2019! Tim will keep working with Angela on selective bromodomain inhibitors!
Both Angela and En-Chih were awarded a department Excellence Fellowship for the 2019/2020 academic year! It is great that their excellent accomplishments have been rewarded! Well-deserved and keep it up.
Congratulations to En-Chih Liu for winning the 2019 Gassman Award for an outstanding talk during the 3rd year graduate symposium: En-Chih spoke about this recently published E-CuAAC reaction: https://chem.umn.edu/news/four-students-earn-paul-and-gerda-gassman-awards
Angela Carlson was awarded an Honorable Mention for her outstanding presentation on Bromodomain inhibitors! Congrats Angela!
Congratulations to senior undergrad James Cox, who won the ACS Division of Organic Chemistry Undergraduate Award in Organic Chemistry! This award is intended to recognize senior students who display a significant aptitude for organic chemistry and to encourage further interest in the field. We're not in anyway surprised, because we are well aware of James' excellence in organic chemistry. Soon though, he will leave us to join the chemistry department at Princeton University! Congrats again James, and we wish you the best of luck in grad school!
Joe wrote a letter to the editor of Chemical and Engineering News, and it was printed! His letter was in response to their article "Science is using the wrong incentives" (https://cen.acs.org/policy/research-funding/Science-using-wrong-incentives/97/i8). If you'd like to read his letter, go to the April 12, 2019 edition of C&EN and read the Reactions section (https://cen.acs.org/acs-news/publishing/Reactions/97/i15)!
Angela's review on the interesting literature surrounding the Winstein Rearrangement was just accepted! Way to go Angela! Writing reviews is a LOT of hard work, but it was definitely worth the effort.
En-Chih's many long hours of working on an enantioselective click reaction have finally paid off, because his paper was just accepted to JACS!
Way to go En-Chih! We're sure this is the first of many!
We got a brand new supercritical fluid chromatography system! It has a mass spec as well (electrospray ionization) so we could get enantiomeric ratios on crude material. How cool! Hopefully this will speed up research!
Welcome to Juliana, our new post-doc! She completed her graduate work with Prof. Matt Cook at Queen's University in Belfast, then worked for Prof. Garret Moraski at the University of Montana in Bozeman. We're excited to have a new face in the lab!
Our grant application titled "Attaining Selectivity for the Inhibition of Bromodomains" was funded by the American Cancer Societies Institutional Research Grant program! The grant is for $30,000 and it will focus on research optimizing the synthesis, potency, and selectivity of a compound discovered in the Pomerantz lab. Keep up the good work, Angela!
Our lab was recogonized and will be a 2019 "Thieme Chemistry Journal Award" winner! According to their website (https://www.thieme.de/en/thieme-chemistry/thieme-chemistry-journals-award-107359.htm), "The Thieme Chemistry Journals Award is presented every year to up-and-coming researchers worldwide who are in the early stages of their independent academic career as assistant or junior professors." Way to go guys!
Congrats to Amy for her latest publication in Org Lett, bringing our total independent publications to 10! Check out her work on racemizing activated azides: Catalytic Racemization of Activated Organic Azides .
Congratulations to Angela, for her contribution to a paper in J. Med. Chem. in collaboration with the Pomerantz and Harki groups here at UMN, as well as the H. Lee Moffitt Cancer Center and Research Institute!
Once again, on STEM day at the state fair, we taught everyone how cool chemistry is! From learning about ocean acidification to making a hidden message (or some slime!) everyone had a good time. Thanks to Market Science (https://marketsci.org/) for helping us spread our love of chemistry!
We went to Linden Hills to share our love of chemistry with a new farmers market! We told them about climate change and how that affects water pH, as well as ocean life, and we showed them how to write secret messages using pH indicators. As always, making slime was DEFINITELY a crowd favorite. To learn more about Market Science, visit their website https://marketsci.org/
We got a new post-doc! We're excited to welcome Dr. Sanjay Maity to the lab. He comes to us from the Ghorai lab at the Indian Institute of Science Education and Research Bhopal. Looking forward to doing cool chemistry with you!
Congratulations to Amy and Mary, whose paper was just accepted in the Journal of Organic Chemistry! If you want to learn more about the multiple mechanisms of the Winstein Rearrangement, click the link! Evidence for a Sigmatropic and an Ionic Pathway in the Winstein Rearrangement
Look at us go! For Spring 2018, we've won yet another Safe Lab Award. Thanks team, for making this a safe and clean lab to work in, and keep up the good work!
For all of those Star Wars fans out there, read our latest publication, ""It's a (Kinetic) Trap!": Selectively Differentiating Allylic Azide Isomers" in Synpacts! Find it on our Publications page, or at https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1609479
Our lab clearly has the best undergrads! Our very own James Cox was named a 2018 Goldwater Scholar (1 out of 211 students picked from 1,280 applicants!) in addition to winning a departmental fellowship! We all knew James was one in a million, but now other people are confirming it.
For more information about James, see the department news page (https://chem.umn.edu/news/james-cox-named-2018-goldwater-scholar).
Our most recent paper (The Effect of Proximal Functionality on the Allylic Azide Equilibrium) was selected to design the cover art for an upcoming issue of the European Journal of Organic Chemistry! The art was done by local artist/illustrator/author Drew Brockington (http://brockart.format.com/).
The Topczewski lab is doing awesome! Two of our members, Amy Ott and Angela Carlson, were recognized at the first departmental seminar. Amy was one of the recipients of a third year Excellence in Graduate Studies Fellowship (the Wayland Noland Fellowship in particular), and Angela was honored for obtaining a 4.0 GPA last year. Wow! Looks like their hard work is paying off (figuratively and literally)!
On Saturday, the Topczewski lab once again showed the Midtown Market that chemistry is fun and interesting! Despite the wind, almost 100 people came to learn about ocean acidification, precipitation reactions, catalysis, and how to make slime!
It's official! The National Institute of Health has officially given us money in the form of a MIRA grant. That's huge for an up-and-coming lab like us. Visit our Funding page to learn about our other funding sources, or, visit the department story (https://chem.umn.edu/news/professor-topczewski-researching-chiral-amines-nih-mira-grant) to see more.
Our lab just keeps churning out the papers! Already, paper number three is in the European Journal of Organic Chemistry. Way to go, Mary, James, and Vicky!
Every semester, the Joint Safety Team (JST) gives out an award for the safest lab. This semester, that lab was ours! Way to go guys for keeping our lab a clean and safe space to do research!
Prof. Topczewski and our second year grad students went to the National Organic Symposium in Davis, CA to share our research with the Organic Chemistry community! The conference was written up in C & EN (http://cen.acs.org/articles/95/i30/Chemists-champion-future-2017-National.html?type=paidArticleContent) and the Top lab learned a lot about what's happening now in our field. We even had time for some fun things, like wine and olive oil tasting!
Congratulations to Vicky, who got a job straight out of undergrad at Phillips 66! Way to go Vicky, we all knew you could do it! Now go show Oklahoma what Topczewski lab students can do.
Congratulations to Amy, Mary, and Matt, who all passed their preliminary exams! Now that they're all done with those hoops, here's hoping they get lots of good research done.
Despite the small size of the incoming class, we managed to snag three more graduate students to join our lab! Welcome to En-Chih Liu, Angela Carlson, and Ryan Daley! En-Chih graduated from National Cheng Kung University in Tainan, Taiwan with his Masters, where he worked on developing methodology for the synthesis of corannulene. Angela Carlson graduated from Augsburg College, and then worked at Isurtec and Medivators. Ryan Daley graduated from St. Olaf, where he worked on palladium-catalyzed arylation of nitroarenes using aryl sulfonates.
Our Chemistry Market Science exhibit was so popular that we got asked back! This time, we went to the Nokomis Farmer's Market. We were so busy though, teaching everyone the joys of chemistry, that we forgot to take pictures. But at least we spread our knowledge and hopefully our love of chemistry.
Welcome to Su Nguyen from University of Mississippi, who will be joining us for 10 weeks thanks to the LANDO program! She'll be working with Amy on functionalization of symmetric allylic azides.
This year at Market Science, we did our own demonstrations, instead of helping others! We're the only physical science exhibitors at Market Science (*gasp*)! Thank goodness we were there to teach our future scientists that chemistry is obviously the best science! We may have lured almost 200 people to our booth with slime, but they had a fun time learning about ideal gas laws, acid/base chemistry, and ocean acidification. Hopefully we inspired some adults too to realize that chemicals aren't that scary at all (but maybe a little messy).
We managed to snag two more graduate students from the incoming class! Welcome Mary Packard and Matt Porter. Mary graduated from University of Puget Sound, and worked on liquid crystals and organogellators with Professors Scharrer and Crane. Matt graduated from Case Western Reserve University and worked in Professor Protasiewicz's lab working on organophosphorous chemistry and Professor Suavé on organovoltaics.
Prof. T and Amy helped out at Market Science at the Midtown Farmer's Market. Market Science "is a collective of scientists from the University of Minnesota, and around the Twin Cities, sharing science through hands-on learning activities for kids, answering scientific questions for market goers, and creating conversations between researchers and their communities." If you want to learn more about it or get involved, go to https://marketsci.org/ !
Three very brave souls volunteered to help Prof. Topczewski get this lab up and running! Two undergraduates from UMN, Vicky Suding (middle) and Rami Shaker (left of Goldy) took on this challenge, as well as incoming graduate student Amy Ott (far left). Amy went to Carroll University and worked with Prof. McMahon on the development of enantioselective organocatalytic methods for the nucleo-acylation of alkenes.
Newly minted Professor Topczewski worked hard to recruit awesome grad students to UMN (and his lab) at recruiting weekend. Lots of schmoozing and science talk may have worked some magic!